The station was built as Gower Street, changing to its present name in 1909. In late 2006 the new entrance on the south side of Euston Road opened in a corner of the new headquarters of the Wellcome Trust replacing the old entrance. There is also a subway entrance on the north side of Euston Road.
In December 2005 Network Rail announced plans [2] to create a subway link between the station and Euston station as part of the re-development of Euston station. This will create a direct link for users of heavy rail services which terminate at Euston.